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α-Linolenic acid

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Catalog No. T3P2904Cas No. 463-40-1
Alias Linolenic acid, Alpha-Linolenic Acid

α-Linolenic Acid (ALA) is an essential fatty acid that cannot be synthesized by the human body and is obtained by isolating it from seed oils. α-Linolenic acid has been shown to improve memory, inhibit thrombosis, and lower blood lipids.

α-Linolenic acid

α-Linolenic acid

🥰Excellent
Purity: 99.81%
Catalog No. T3P2904Alias Linolenic acid, Alpha-Linolenic AcidCas No. 463-40-1
α-Linolenic Acid (ALA) is an essential fatty acid that cannot be synthesized by the human body and is obtained by isolating it from seed oils. α-Linolenic acid has been shown to improve memory, inhibit thrombosis, and lower blood lipids.
Pack SizePriceAvailabilityQuantity
50 mg102 €In Stock
100 mg151 €In Stock
500 mg379 €In Stock
1 mL x 10 mM (in DMSO)42 €In Stock
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Purity:99.81%
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Product Introduction

Bioactivity
Description
α-Linolenic Acid (ALA) is an essential fatty acid that cannot be synthesized by the human body and is obtained by isolating it from seed oils. α-Linolenic acid has been shown to improve memory, inhibit thrombosis, and lower blood lipids.
In vitro
METHODS: Osteosarcoma cells MG63, 143B and U2OS were treated with α-Linolenic Acid (10-200 µM) for 24 h. Cell viability was determined by MTT assay.
RESULTS: α-Linolenic Acid showed a highly inhibitory effect on cell proliferation in a dose-dependent manner, with IC50 values of 51.69±0.14 µM in MG63 cells, 56.93±0.23 µM in 143B cells and 49.8±0.50 µM in U2OS cells.[1]
METHODS: Breast cancer cells MDA-MB-231 and MCF-7 were treated with α-Linolenic Acid (25-100 µM) for 24 h. Apoptosis was detected by flow cytometer.
RESULTS: The percentage of apoptotic cells in the early (from 2.9% to 23.5% and from 5.5% to 16.7%, respectively) and late (from 0.6% to 3.4% and from 2.0% to 13.8%, respectively) apoptotic stages was significantly increased in MDA-MB-231 and MCF-7 cells treated with 100 µM α-Linolenic Acid. percentage significantly increased, which was significantly higher compared to untreated control cells. [2]
In vivo
METHODS: To study the therapeutic effect on colitis in mice, α-Linolenic Acid (150-300 mg/kg, dispersed in 0.25% Tween-20) was administered by gavage to HFHSD-fed BABL/c mice once daily for nine weeks. At the end of nine weeks, experimental colitis was induced by intracolonic injection of TNBS.
RESULTS: Low α-Linolenic Acid administration significantly ameliorated TNBS-induced clinical manifestations, body weight loss, spleen weight loss, and histologic damage. In contrast, high α-Linolenic Acid administration did not improve colitis and even exacerbated symptoms.HFHSD exacerbated TNBS-induced colitis via the Th1/Th17 pathway. Low α-Linolenic Acid showed a protective effect against TNBS-induced colitis via the Th1/Th2/Th17 pathway. [3]
AliasLinolenic acid, Alpha-Linolenic Acid
Chemical Properties
Molecular Weight278.43
FormulaC18H30O2
Cas No.463-40-1
SmilesCC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O
Relative Density.0.914 g/cm3 at 25℃ (lit.)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 100 mg/mL (359.16 mM), Sonication is recommended.
DMSO: 100 mg/mL (359.16 mM), Sonication is recommended.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM3.5916 mL17.9578 mL35.9157 mL179.5784 mL
5 mM0.7183 mL3.5916 mL7.1831 mL35.9157 mL
10 mM0.3592 mL1.7958 mL3.5916 mL17.9578 mL
20 mM0.1796 mL0.8979 mL1.7958 mL8.9789 mL
50 mM0.0718 mL0.3592 mL0.7183 mL3.5916 mL
100 mM0.0359 mL0.1796 mL0.3592 mL1.7958 mL

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